COMPLICATIONS IN HEPATIC PROTEINS AND NUCLEIC ACIDS METABOLISM UNDER THE INFLUENCE OF BAYTHROID TOXICITY IN RATS AT DIFFERENT THYROID STATES

الملخص

The influence of different thyroid dysfunctions on the toxicity of pyrethroid insecticide (baythroid) was studied. Groups of experimental animals (Rattus rattus) were prepared to be in authyroid, hypothyroid and hyperthyroid states. The effects of acute (LD50) as well as subchronic (1/10 LDS0 day 10) of buythroid were investigated The data recorded revealed that oral injection of euthyroid rats with either acute or multiple doses of baythroid induced marked reduction in total serum and liver proteins. In contrast, the levels of amino acids in serum and liver were markedly increased. Moreover, there effects run in parallelisan with reductions in hepatic nucleic acids (RNA & DNA) contents. The modifications in proteins, amino acids and nucleic acids metabolism under the stress of buythroid were also followed-up during different thymid states. The results obtained were discussed