Khat effect on the conduction velocity of nerve fibers in Toad

Abstract

 Conduction velocity of sciatic of sciatic nerve of toad Buformelano
stiticuts was studied by khat extract.
Experiments were done by determining the dose dependent of khat using
on nerve fiber and as believed khat like amphetamine can relive pain as
same as ibuprofen1 has psycho stimulant mediated by dopamine so the
groups of experiment that was studied the conduction velocity of the
sciatic nerve after pretreatment by khat, then was determined the
affected nerve by khat after treatment with haloperidol which known as
a dopaminergic blocker.
Results were demonstrated that after khat treatment there was a
decrease in latent period decrease in the time taken to disseminate
excitation through nerve and there was increase in conduction velocity
while on the contrary after treatment with haloperidol the latent period
and the time taken to propagate provocation along nerve fiber increased
with decrease in conduction velocity. accordingly it possibly that khat
type of excitant drug , causes increase the conduction velocity of sciatic
nerve due to its effects that mediated by dopamine and reverses these
effects by haloperidol .